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Zn coordination by DksA may attenuate its redox-sensing activity, reserving the redox-sensing Cys pair to respond only under conditions of chronic ROS stress, where cellular reductant pools become depleted
For example, studies have indicated that oral glutathione (500 mg twice daily) may significantly reduce skin pigmentation in participants
doi: 10.4049/jimmunol.178.12.7649
Toxicol Appl Pharmacol 182:8490 Morkunaite-Haimi S, Kruglov AG, Teplova VV, Stolze K, Gille L, Nohl H, Saris NE (2003) Reactive oxygen species are involved in the stimulation of the mitochondrial permeability transition by dihydrolipoate
A conserved dual function of the conserved lysine residue for redox catalysis is also supported by previous studies: Lys19 of human Grx1 and Lys8 of NrdH-redoxin from C
In breast cancer cells, a variety of TFs are important for cell survival, growth, metastasis, and division
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